The hacienda de Chichimequillas is located in the municipality of El Marqués, Querétaro. It was built around 1690 by Carmelite monks who settled in the area to assist and settle the Chichimeca Jonaces and Pame indigenous people, while also providing shelter to travelers journeying along the Camino Real de Tierra Adentro to and from the mining regions of Guanajuato and Zacatecas.

The former hacienda of Ciénaga de Mata is located in the town of Francisco Primo de Verdad, municipality of Lagos de Moreno, Jalisco. It was formerly known as Ciénaga de Rincón, named after the prestige achieved by the Rincón Gallardo family, also Marquises of Guadalupe. The proximity of this area to Zacatecas and other mining centers in need of grains and meat was an incentive for the first men who owned titles and land to become interested in making the area productive, despite its hostility.

The former hacienda of Ciénaga de Mata is located in the town of Francisco Primo de Verdad, municipality of Lagos de Moreno, Jalisco. It was formerly known as Ciénaga de Rincón, named after the prestige achieved by the Rincón Gallardo family, also Marquises of Guadalupe. The proximity of this area to Zacatecas and other mining centers in need of grains and meat was an incentive for the first men who owned titles and land to become interested in making the area productive, despite its hostility.

The Hacienda de la Limpia Concepción de El Canutillo, located in the current municipality of Ocampo, Durango, dates back to the second half of the 17th century. Originally built as an agricultural estate, its primary function was to supply the mining center of Parral (Chihuahua). However, it eventually became one of the wealthiest haciendas in the region due to its proximity to the Río Florido, which facilitated irrigation and thereby increased productivity.

The hacienda Pabellón de Hidalgo, like most haciendas in Aguascalientes, owes its existence to the investment of miners from Zacatecas. The properties of Garabato and San Isidro, acquired by the Zacatecan miner José de la Peña Durán in 1681, would eventually give rise to the hacienda of Pabellón de Hidalgo.

The hacienda of Peñuelas was founded in 1612, making it one of the oldest in Aguascalientes. Originally established under the name San Isidro Labrador, this name fell out of use because people began referencing the rocky landscape of the area, leading to the appellation that has persisted to this day.

The Hacienda de San Diego de Navacoyán, located on the banks of the Tunal River in the present-day state of Durango, was another significant stop on the itinerary of the Camino Real de Tierra Adentro. Travelers needed to cross this river to continue their route towards Chihuahua and New Mexico.

The Franciscan order had a prolific presence in various parts of New Spain, particularly in what is now the state of Zacatecas. On January 12, 1707, Fray Antonio Margil de Jesús, along with ten other Franciscans, founded the College of Our Lady of Guadalupe de Propaganda Fide on the outskirts of Zacatecas. This institution interacted with its counterpart in Santa Cruz de Querétaro along the Camino Real de Tierra Adentro. Construction took place between 1713 and 1717, overseen by Father Guardian José Guerra.

Located in the municipality of Tepotzotlán, State of Mexico, the ancient Conciliar College and Seminary of San Francisco Javier, of the Society of Jesus, was for many generations a pilgrimage site for the Chichimeca until the formal establishment of the independent lordship of Tepotzotlán in 1460 during the 15th century.

During the colonial era, the current territory of the state of Hidalgo was of great importance due to its missionary activity. Several churches and convents were founded in what was called the Province of the Holy Gospel, which were under the jurisdiction of the Archdiocese of Mexico. The extensive missionary activity began in the pre-Hispanic center of Tula, led by the Franciscans, the first order to arrive in the province. Additionally, the first significant mines near Mexico City were discovered in the state of Hidalgo.

The old Hospital of San Juan de Dios in the city of San Miguel de Allende, Guanajuato, also known as the Royal Hospital, is a work attributed to Father Juan Manuel de Villegas, who was in charge of its construction in 1753.

During the 16th century, the Spanish crown attempted to populate the territory of the former encomienda of Jilotepec, located on the Chichimeca frontier. This effort aimed to protect the road leading from Mexico City to the northern territories of New Spain.