This city preserves architectural features typical of the Bajío region and is closely linked to significant historical events that took place during the War of Independence, the Second French Intervention, and the Mexican Revolution.

The Camino Real de Tierra Adentro includes five sites already inscribed on the World Heritage List and 55 other sites distributed along 1,400 of the 2,600 km of this long route that starts in northern Mexico and reaches Texas and New Mexico in the United States. Used between the 16th and 19th centuries, this road was used to transport silver extracted from the mines of Zacatecas, Guanajuato and San Luis Potosí, as well as mercury imported from Europe. Although its origin and use are linked to mining, the Camino Real de Tierra Adentro also fostered the establishment of social, cultural and religious links between Hispanic and Amerindian cultures.

The Hospicio Cabañas was built at the beginning of the 19th century to provide care and shelter for the disadvantaged – orphans, old people, the handicapped and chronic invalids.

The old colonial town of Querétaro is unusual in having retained the geometric street plan of the Spanish conquerors side by side with the twisting alleys of the Indian quarters. The Otomi, the Tarasco, the Chichimeca and the Spanish lived together peacefully in the town, which is notable for the many ornate civil and religious Baroque monuments from its golden age in the 17th and 18th centuries.

Initiated by the Franciscan friar, Tembleque, and built with the local indigenous communities, this hydraulic system is an example of the exchange of influences between the European tradition of Roman hydraulics and traditional Mesoamerican construction techniques, including the use of adobe. The site incorporates the highest single-level arcade ever built in an aqueduct.

The Mayan town of Uxmal, in Yucatán, was founded c. A.D. 700 and had some 25,000 inhabitants. The layout of the buildings, which date from between 700 and 1000, reveals a knowledge of astronomy. The Pyramid of the Soothsayer, as the Spaniards called it, dominates the ceremonial centre, which has well-designed buildings decorated with a profusion of symbolic motifs and sculptures depicting Chaac.

The Earliest 16th-Century Monasteries on the Slopes of Popocatepetl is a serial property with 15 component parts located in the states of Morelos, Puebla and Tlaxcala in Mexico, built as part of the evangelisation and colonisation of the northern territories of Mexico.

Founded in 1546 after the discovery of a rich silver lode. Built on the steep slopes of a narrow valley, the town has breathtaking views and there are many old buildings. The cathedral, built between 1730 and 1760, dominates the centre of the town. It is notable for its harmonious design and the Baroque profusion of its façades, where European and indigenous decorative elements are found.

Morelia is an example of urban planning which combines the ideas of the Spanish Renaissance with the Mesoamerican experience. More than 200 historic buildings, all in the region's characteristic pink stone, reflect the town's architectural history, revealing a masterly and eclectic blend of the medieval spirit with Renaissance, Baroque and neoclassical elements.

Founded by the Spanish in the early 16th century, Guanajuato became the world's leading silver-extraction centre in the 18th century.