This city preserves architectural features typical of the Bajío region and is closely linked to significant historical events that took place during the War of Independence, the Second French Intervention, and the Mexican Revolution.

The Camino Real de Tierra Adentro includes five sites already inscribed on the World Heritage List and 55 other sites distributed along 1,400 of the 2,600 km of this long route that starts in northern Mexico and reaches Texas and New Mexico in the United States. Used between the 16th and 19th centuries, this road was used to transport silver extracted from the mines of Zacatecas, Guanajuato and San Luis Potosí, as well as mercury imported from Europe. Although its origin and use are linked to mining, the Camino Real de Tierra Adentro also fostered the establishment of social, cultural and religious links between Hispanic and Amerindian cultures.

Paquimé, Casas Grandes, played a key role in trade and cultural contacts between the Pueblo culture of the south-western United States and northern Mexico and the more advanced civilizations of Mesoamerica. The extensive remains are clear evidence of the vitality of a culture which was perfectly adapted to its physical and economic environment, but which vanished at the time of the Conquest.

The Hospicio Cabañas was built at the beginning of the 19th century to provide care and shelter for the disadvantaged – orphans, old people, the handicapped and chronic invalids.

This Valley, with the richest biodiversity in North America, consisting of Zapotitlán-Cuicatlán, San Juan Raya and Purrón, it is one of the main centres of diversification for the cacti family, which is critically endangered worldwide. The valley presents an exceptional water management system of canals, wells, aqueducts and dams, the oldest in the continent.

The old colonial town of Querétaro is unusual in having retained the geometric street plan of the Spanish conquerors side by side with the twisting alleys of the Indian quarters. The Otomi, the Tarasco, the Chichimeca and the Spanish lived together peacefully in the town, which is notable for the many ornate civil and religious Baroque monuments from its golden age in the 17th and 18th centuries.

Initiated by the Franciscan friar, Tembleque, and built with the local indigenous communities, this hydraulic system is an example of the exchange of influences between the European tradition of Roman hydraulics and traditional Mesoamerican construction techniques, including the use of adobe. The site incorporates the highest single-level arcade ever built in an aqueduct.

The Earliest 16th-Century Monasteries on the Slopes of Popocatepetl is a serial property with 15 component parts located in the states of Morelos, Puebla and Tlaxcala in Mexico, built as part of the evangelisation and colonisation of the northern territories of Mexico.

Founded in 1546 after the discovery of a rich silver lode. Built on the steep slopes of a narrow valley, the town has breathtaking views and there are many old buildings. The cathedral, built between 1730 and 1760, dominates the centre of the town. It is notable for its harmonious design and the Baroque profusion of its façades, where European and indigenous decorative elements are found.

El Tajín's architecture, which is unique in Mesoamerica, is characterized by elaborate carved reliefs on the columns and frieze. The 'Pyramid of the Niches', a masterpiece of ancient Mexican and American architecture, reveals the astronomical and symbolic significance of the buildings. El Tajin has survived as an outstanding example of the grandeur and importance of the pre-Hispanic cultures.