Hacienda de la Zarca, located in the present-day municipality of Hidalgo, was initially one of the first and largest cattle ranches in the state of Durango. This hacienda was an important stop along the itinerary of the Camino Real de Tierra Adentro, serving as a mandatory resting point for travelers journeying from the mines of Parral to Durango or Fresnillo.

During the colonization process in northern New Spain, the mining district of San Juan Bautista de Indehe—later known as Indé in the 19th century—gained special significance as one of the first mining districts in Nueva Vizcaya.

In the late 16th century, Franciscan missionaries from Cuencamé entered the Mapimí region with the objective of carrying out their evangelizing work, founding several short-lived towns for this purpose.

San Pedro del Gallo, also known as Ojo del Gallo, is currently located in the municipality of the same name, in the stretch that connected the Nazas River and the Zarca plateau. This route was formerly known as the Carretas Path and is situated in a semi-desert region of the Bolsón de Mapimí. In this area, there is a water spring, which made the region a resting place for travelers on the Royal Inland Road where they could graze their horses.

The significance of the ancient mission of the Cinco Señores del Río Nazas, now Nazas, on the itinerary of the Camino Real de Tierra Adentro is due to its strategic location.

The hacienda of La Limpia Concepción de Palmitos de Abajo is located in the Palmitos Valley, in the present-day municipality of Rodeo, in the state of Durango. One of the first expeditions to this site was carried out by Juan de Oñate in 1596. Subsequently, the favorable characteristics of the area increased Spanish interest in occupation, as it boasts abundant water resources and fertile land suitable for wheat cultivation and fruit trees.

The agricultural hacienda of La Inmaculada Concepción de Palmitos de Arriba is located in the Palmitos Valley, in the present-day state of Durango. It was an important site along the itinerary of the Camino Real de Tierra Adentro, serving as a resting place for travelers heading from the city of Durango to the silver mines of San José de Parral and vice versa.

One of the first mining towns established north of Zacatecas was the town of San José de Avino, discovered by Captain Francisco de Ibarra in 1554. However, its exploitation began several years later, around 1630. Despite this, it was abandoned for long periods and was re-exploited around 1730 by the Basque José de Echaez. It was during this time that the name "Real de San José del Avinito" was formally adopted.

The Chapel of Our Lady of Refuge in the former hacienda of San Juan de la Noria, Cuatillos or Pedriceña, is located in the municipality of Cuencamé, Durango. It was built in the 17th century as an agricultural and livestock estate.

Jesuit missionaries were the founders of the mining towns of San Antonio de Cuencamé and Mapimí. This religious order was also responsible for spreading the veneration of the Señor de Mapimí in these areas, which became one of the most important religious traditions in Nueva Vizcaya since the 18th century.