The Camino Real de Tierra Adentro includes five sites already inscribed on the World Heritage List and 55 other sites distributed along 1,400 of the 2,600 km of this long route that starts in northern Mexico and reaches Texas and New Mexico in the United States. Used between the 16th and 19th centuries, this road was used to transport silver extracted from the mines of Zacatecas, Guanajuato and San Luis Potosí, as well as mercury imported from Europe. Although its origin and use are linked to mining, the Camino Real de Tierra Adentro also fostered the establishment of social, cultural and religious links between Hispanic and Amerindian cultures.

The House and Studio of architect Luis Barragán represents an outstanding example of the architect’s creative work in the post-Second World War period. Barragán’s work integrated modern and traditional artistic and vernacular currents and elements into a new synthesis, which has been greatly influential, especially in the contemporary design of gardens, plazas and landscapes.

Built in the 16th century by the Spanish on the ruins of Tenochtitlan, the old Aztec capital, Mexico City is now one of the world's largest and most densely populated cities. Xochimilco lies 28 km south of Mexico City. With its network of canals and artificial islands, it testifies to the efforts of the Aztec people to build a habitat in the midst of an unfavourable environment.

The ensemble of buildings, sports facilities and open spaces of the Central University City Campus of the Universidad Nacional Autónoma de México (UNAM) are an unique example of 20th-century modernism integrating urbanism, architecture, engineering, landscape design and fine arts with references to local traditions, especially to Mexico’s pre-Hispanic past.