The Camino Real de Tierra Adentro includes five sites already inscribed on the World Heritage List and 55 other sites distributed along 1,400 of the 2,600 km of this long route that starts in northern Mexico and reaches Texas and New Mexico in the United States. Used between the 16th and 19th centuries, this road was used to transport silver extracted from the mines of Zacatecas, Guanajuato and San Luis Potosí, as well as mercury imported from Europe. Although its origin and use are linked to mining, the Camino Real de Tierra Adentro also fostered the establishment of social, cultural and religious links between Hispanic and Amerindian cultures.

This site museum features lithographs that reproduce rock paintings estimated to be around three thousand years old.

Founded by the Spanish in the early 16th century, Guanajuato became the world's leading silver-extraction centre in the 18th century.

The fortified town, first established in the 16th century to protect the Royal Route inland, reached its apogee in the 18th century when many of its outstanding religious and civic buildings were built in the style of the Mexican Baroque. The Sanctuary of Atotonilco's architecture and interior decoration testify to the influence of Saint Ignacio de Loyola’s doctrine.

One of the most complex cities of the region, found in the southern foothills of the Pénjamo Range. It stands out because of its integration with the countryside (it was carefully built to preserve the harmony of its surroundings). Plazas, palaces, sculpture and thousands of splendid stone carvings await the visitor.

One of the largest sites in the Bajío region (330-750 AD), there is still a mystery about the ethnic origin of the people who inhabited it. The magnificent architecture is monumental, suggesting a ceremonial center.

The historical vestiges preserved in Mineral de Pozos reveal the wealth that emerged from the silver mining that long characterized the town. Its cobbled streets enclose colonial buildings of historical value and great beauty.

First established as a small congregation in the viceregal period, this city is today a symbol of Mexican nationalism, because it was in the Church of Our Lady of Sorrows that the priest Miguel Hidalgo y Costilla proclaimed the Cry of Dolores in 1810. The city is also known as the birthplace of the Mexican composer José Alfredo Jiménez.