The origins of the hacienda of San José de Cieneguilla, in the state of Aguascalientes, date back to 1616 when the marriage of Vicente de Zaldívar y Mendoza and Ana Bañuelos acquired the lands, subsequently donating the property to the Jesuit Company of Zacatecas to support the San Luis college located there. The donation included lands and their buildings, mules, donkeys, horses, mares, carts, tools, farming implements, corn plantations, fruit seeds, blacksmithing work, and indigenous labor services.

The hacienda of Peñuelas was founded in 1612, making it one of the oldest in Aguascalientes. Originally established under the name San Isidro Labrador, this name fell out of use because people began referencing the rocky landscape of the area, leading to the appellation that has persisted to this day.

The plains of the Teocaltiche Valley, an area of Chichimeca towns, were an important crossing point for communication routes between Zacatecas and Mexico City and Guadalajara. This facilitated the emergence of a successful agricultural and livestock economy. The Altos de Jalisco soon became, along with Aguascalientes, suppliers to the mining settlements in the north, leading to the founding in 1760 of the town of Nuestra Señora de la Encarnación de los Macías, at the former post of El Sauz.

The former hacienda of Ciénaga de Mata is located in the town of Francisco Primo de Verdad, municipality of Lagos de Moreno, Jalisco. It was formerly known as Ciénaga de Rincón, named after the prestige achieved by the Rincón Gallardo family, also Marquises of Guadalupe. The proximity of this area to Zacatecas and other mining centers in need of grains and meat was an incentive for the first men who owned titles and land to become interested in making the area productive, despite its hostility.

During the 16th century, the intense traffic of mule trains, wagon caravans, and indigenous carriers traveling daily along the Royal Inland Road between the presidios of El Portezuelo and Ojuelos made it necessary to implement permanent infrastructure that would allow for vehicle passage throughout the year.

During the second half of the 16th century, indigenous groups persisted in resisting the Spanish presence and constantly attacked the muleteers and the goods they transported along the Camino Real de Tierra Adentro. This traffic increased following the mining discoveries in northern New Spain, creating a need to improve the transportation of goods, supplies, and metals through hostile territories. The security measures implemented included the establishment of forts or presidios. These forts represented elements of defense, security, and pacification of the rebellious groups and later served to populate territories.

The historic center of Lagos de Moreno is located northeast of Guadalajara, the capital of the state of Jalisco. During the second half of the 16th century, this area was turned into a war zone by the Chichimeca people. In response, as part of strategies for pacification and protection of the Spanish settlers, Viceroy Luis Velasco ordered the construction of forts, garrisons, or bulwarks at strategic points along the Camino Real de Minas. These fortifications housed contingents of soldiers who would patrol the road and accompany travelers to defend them from Chichimeca attacks.

The Villa Protectora de San Miguel el Grande and Sanctuary of Jesús Nazareno de Atotonilco is located in the north-central region of Guanajuato, which before the arrival of the Spanish was occupied by Chichimec Indians extending from Chamacuero to Guanajuato and San Felipe. The first contacts between the natives and the Spanish occurred in the 1520s, but colonization would not take place until 1542.

The La Quemada Bridge is located on the grounds of the former Hacienda San José de la Quemada, in the municipality of San Felipe, Guanajuato, on the way to Dolores Hidalgo. Both the origins of the hacienda and the bridge date back to the second half of the 16th century.