In 1540, Bishop Vasco de Quiroga founded the San Nicolás Obispo Seminary College for young Spaniards in this building, where indigenous people were taught free of charge. This college, the oldest on the continent, was moved to Valladolid in 1580. The Baroque façade was built in the 18th century, and an arcade was added to the courtyard. In 1869, it was established as a School of Arts and Crafts, and a year later, this school was taken over by the city's artisans. In the second half of the 20th century, the building was restored to adapt it to its new function as the Regional Museum of Popular Arts, which exhibits textiles, ceramics, lacquerware, and masks from the region.