The Camino Real de Tierra Adentro includes five sites already inscribed on the World Heritage List and 55 other sites distributed along 1,400 of the 2,600 km of this long route that starts in northern Mexico and reaches Texas and New Mexico in the United States. Used between the 16th and 19th centuries, this road was used to transport silver extracted from the mines of Zacatecas, Guanajuato and San Luis Potosí, as well as mercury imported from Europe. Although its origin and use are linked to mining, the Camino Real de Tierra Adentro also fostered the establishment of social, cultural and religious links between Hispanic and Amerindian cultures.

Paquimé, Casas Grandes, played a key role in trade and cultural contacts between the Pueblo culture of the south-western United States and northern Mexico and the more advanced civilizations of Mesoamerica. The extensive remains are clear evidence of the vitality of a culture which was perfectly adapted to its physical and economic environment, but which vanished at the time of the Conquest.

Impressive remains of habitation in the zone which date back to 5500 years BC, the oldest in Arid America and all of Mexico. Remarkable for the enormous communal granary in the shape of a cooking vessel, marvellously preserved, with a structure of twisted dry leaves covered in clay.

This site is famous for its adobe constructions and its T-shaped doors, which demonstrates the architectural skills of its ancient inhabitants. Toward the west of the city there is a row of structures built with stone and mortar which were probably coated in painted lime, and functioned as a ceremonial center.

An important agricultural center and historical city where in 1811, in the San Francisco Monastery, the heads of the fathers of Mexican Independence were put on display, to the horror of the local population: Miguel Hidalgo, Ignacio Allende, Juan Aldama and Mariano Jiménez.

Mining town of great importance during the colonial period, and the site where in 1923 one of the main leaders of the Mexican Revolution, Francisco Villa, was assassinated. Today it is recognized as the second municipality in the state of Chihuahua with the most historical monuments.