On December 8, 1659, it was inaugurated under the name Nuestra Señora de Guadalupe del Paso del Río del Norte. It was founded by the Franciscan missionary Fray García with the design by engineer Manuel O'Reilly. It was restored between 1966 and 1967 by architect Felipe Lacouture.

Its construction began in 1885 and was completed in 1889. It was used as a barracks during the Revolution, and the Treaties of Ciudad Juárez were signed within its walls in 1911. It was later used as customs offices until 1978.