Morelia is an example of urban planning which combines the ideas of the Spanish Renaissance with the Mesoamerican experience. More than 200 historic buildings, all in the region's characteristic pink stone, reflect the town's architectural history, revealing a masterly and eclectic blend of the medieval spirit with Renaissance, Baroque and neoclassical elements.

Founded by the Spanish in the early 16th century, Guanajuato became the world's leading silver-extraction centre in the 18th century.

The holy city of Teotihuacan (the place where the gods were created) it is characterized by the size of its monuments –in particular, the Temple of Quetzalcoatl and the Pyramids of the Sun and the Moon, laid out on geometric and symbolic principles. As one of the most powerful cultural centres in Mesoamerica, it extended its cultural and artistic influence throughout the region, and even beyond.

The 34,658 ha site, between the foothills of the Tequila Volcano and the deep valley of the Rio Grande River, is part of an expansive landscape of blue agave, shaped by the culture of the plant used since the 16th century to produce tequila spirit and for at least 2,000 years to make fermented drinks and cloth.