The cultural landscape of the Prehistoric Caves of Yagul and Mitla demonstrates the link between man and nature that gave origin to the domestication of plants in North America, thus allowing the rise of Mesoamerican civilizations.

The fortified town, first established in the 16th century to protect the Royal Route inland, reached its apogee in the 18th century when many of its outstanding religious and civic buildings were built in the style of the Mexican Baroque.

From c. 100 B.C. to A.D. 1300, the Sierra de San Francisco was home to a people who have now disappeared but who left one of the most outstanding collections of rock paintings in the world. They are remarkably well-preserved because of the dry climate and the inaccessibility of the site.