The interior of the Cueva de las Mulas houses rock art associated with the presence of mules and other animals brought by the Spaniards conquistadors to the region during the 14th and 17th centuries. It is located in the Molino Canyon, in the Guatimapé Valley, within the municipality of Nuevo Ideal, in the state of Durango.

Its location on the high part of the Sierra de Tlacotes, in the Cuisilique Valley, municipality of Ojocaliente, in the state of Zacatecas, makes Cueva de Ávalos a natural lookout point from which there is a panoramic view of the towns of Ojocaliente, El Refugio, and Palmillas, a region through which the Camino Real de Tierra Adentro extended.