This gallery offers a general overview of Mesoamerica. The artifacts are arranged by region of origin, beginning with ceramic and bone objects from the Tlatilco peoples, featuring Olmec-style traits. The next section showcases ceramics from western Mexico, created by groups who inhabited present-day Nayarit, Colima, Jalisco, and Michoacán.

Also on display are funerary urns representing "Cocijo", the Zapotec rain god, and geometric-patterned Mixtec ceramics from the Oaxaca region. From the cultures of the Central Valleys, there are various objects such as obsidian-carved jewelry, and ceramic vessels for domestic, ritual, and ceremonial use from the Teotihuacan and Mexica civilizations. The Gulf Coast region is represented by objects and stone sculptures from the Totonac and Olmec cultures.

The exhibition concludes with the Maya region, represented by figurines from Jaina Island in Campeche and ceramic vessels from the surrounding area.