This section presents the pre-Hispanic settlements of Acapulco and the ethnic groups that lived in the region at the time of the Spanish Conquest.

In the 16th century, the Acapulco region was inhabited by various Indigenous groups. Among the most prominent were the Yopes and Tepuztecos. Each group was governed by local rulers, forming a network of semi-independent communities. These groups maintained different relationships, including trade partnerships, military alliances, and shared customs, which together shaped a distinct cultural region.