This gallery presents a collection of pre-Hispanic objects that reveal the ancient history of San Miguel de Allende. Its name comes from the Nahuatl word "Izcuinapan", meaning "water of dogs," the name given to the area’s first Indigenous settlement in the 16th century.

The exhibit includes 135 pieces—luxury items, hunting tools, and everyday objects—dating from 600 BCE to 1050 CE. This permanent exhibition offers insight into the daily life and cultural evolution of the groups that inhabited the Laja River basin, a crossroads for exchange among different ethnic groups in the Bajío region.
Among the pieces are ceramic objects, obsidian and green-blue stone tools, shell necklaces, and hunting instruments from archaeological sites such as Cruz del Palmar, Tierra Blanca, and Cañada de la Virgen. Two thousand artifacts were recovered by the Museo Histórico Casa de Allende, collected by local cultural promoter Miguel Malo Zozaya.

The gallery's curatorial script was developed by archaeologist Gabriela Zepeda García-Moreno of the INAH Guanajuato Center, and historian Alberto Aveleyra Talamantres. Exhibition design was by Marco Barrera Bassols, with support from the National Coordination of Museums and Exhibitions of INAH.