This collection, one of the most important in the museum, showcases objects made of gold, emeralds, and other precious stones, along with silver macuquinas coins recovered from the exploration of the Ancla Macuca shipwreck in the Alacranes Reef, Gulf of Mexico. The collection consists of 211 pieces, including gold, emeralds, amethyst, a ruby, and red coral. These items are considered part of the cargo of a goldsmith who worked during the journey, crafting jewelry and carrying tools and gold sheets as raw material.

These pieces were meant for the everyday life of a European social class and include rings, charms, cufflinks, buttons, toothpicks, chains, and liturgical items such as mantle applications, medals, rosaries (gold and red coral), relics, and crosses. The museum also displays key items related to the ship, including the lead coating of the hull, nails, and bronze bolts, as well as navigation instruments like an anchor and lead line, and weapons, including a musket, fusils, and light armament, alongside war provisions used aboard the ships. Additionally, various items such as ballast, jars, barrel hoops, and spouts from shipwrecks on the Alacranes Reef showcase the cargo storage system aboard these vessels.