Huitzilopochtli is the god of war, a solar deity, and the patron of the Mexicas. Under his guidance, this people became the most powerful civilization in the Mesoamerican region during the Postclassic period.

In this room, various objects related to Huitzilopochtli are displayed. Among the most notable is the sculpture known as the "Eagle Warrior," found in the House of the Eagles, a religious building located north of the Temple Mayor. Studies by Dr. Leonardo López Luján offer a different interpretation of these figures, calling them Eagle Men, representing the rising sun or the Tlatoani (ruler) who is reborn after being chosen as the leader. Additionally, a representation of Mictlantecuhtli, the god of death, stands out among the exhibited pieces.

Other significant objects from this room, found on the side associated with Huitzilopochtli, include the representation of Mayahuel, the goddess of pulque; one of the several reliefs of the "Lord of the Earth," Tlaltecuhtli; several sculptures of the god of fire, Xiuhtecuhtli-Huehuetéotl; and, undoubtedly, the great Coyolxauhqui monolith, which is linked to the myth of Huitzilopochtli’s birth. Coyolxauhqui is the lunar goddess who lies dismembered and was discovered on February 21, 1978.