This section focuses on the work carried out in the center of Mexico City, specifically in the area that housed the Ceremonial Center of Tenochtitlan.

In this room, visitors can learn about artifacts and sculptures found throughout the history of explorations in the Mexico City center. Key pieces include the basalt head of the god Xólotl found at Las Escalerillas, the Cuauhxicalli Eagle discovered at the Marqués del Apartado House, the recent findings at the Metropolitan Cathedral, and three examples of the main types of offerings discovered at the most important Mexica building: the Temple Mayor.

This room is dedicated to the most important archaeological finds in this area. Highlights include those of Coatlicue and the Sun Stone (Piedra de Sol), studied by León y Gama in 1790. The exhibit also showcases some works by Baron Alexander von Humboldt, as well as samples from the first excavations carried out in the early 20th century by Leopoldo Batres and Manuel Gamio, among others.