This section showcases the productive and domestic activities of the Chalchihuites population. Remarkably, the artifacts are linked to specific activities, and these activities are in turn associated with individuals, highlighting their social roles. Labor division followed gender and age roles.

Agriculture was the main source of food, complemented by the gathering and hunting of naturally available resources that varied according to the seasons. Other activities included working with fibers to manufacture ropes, mats, baskets, and nets. Equally important were stone tool production and ceramic manufacturing. The instruments on display are associated with these tasks and include axes, hammers, whetstones, sharpeners, knives, blades, grinding stones and hands, pots, bowls, plates, and jars. These come in red, black, and cream tones, with some pieces polished, brushed, or decorated with incised nail marks.

The panel of the daily life display case presents aspects of agriculture in relation to cultivated lands. It also illustrates the layout of village settlements, which were made up of square or rectangular patios outlined by raised walkways with stepped entrances, among other features. The display further includes elements of the flora and fauna that were present during the occupation of the region.

Another key activity in the area was mining, forming one of the most extensive industries in all of Mesoamerica. This section presents mining extraction techniques, the technologies used inside the mines, and the minerals sought, such as weathered flint, quartz, pyrite, and hematite. Some of these were used to manufacture ornamental items, while others served as pigments.

Also within this section, skeletal remains are displayed. These help identify possible physical characteristics and hereditary, occupational, climatic, dietary, and cultural factors.