The upper level of the building was constructed between 1750 and 1774. Its walls are decorated with monumental paintings by some of the most renowned 18th-century artists, including Miguel Cabrera, José de Ibarra, and Nicolás Rodríguez Juárez. Three of the largest canvases—by Cabrera and José Ríos Arnáez—were designed specifically for this space. This iconic area of the Museo de Guadalupe exemplifies the splendor of Mexican Baroque art.

The building is unique among the former Propaganda Fide Colleges in that much of its original artwork remains in situ. The grand staircase, choir, and upper and lower cloisters all bear witness to this remarkable preservation.