The Cholula Archeological Site Museum was opened in 1945 even before the first stage of the site’s archeological excavation—which took place between 1931 and 1956—had been formally concluded. The museum is in a modern building which has undergone a few transformations in the nearly 70 years it has been standing. At first the model of the Great Pyramid of Cholula represented its final stage of development and did not include the Church of the Virgin of Los Remedios on its peak, although it did include a profile of the dimensions and architectural style of its final stage. At the end of the second phase of excavations, from 1967 to 1971, a second gallery was added and the model was modified, now situated in a recess at the back of the first gallery. The Church of the Virgin of Los Remedios was added to the model with the patios of the south and west sectors which had now been excavated. This modification implied the removal of the profile which simulated the last building stage of the Great Pyramid. A few years later a third gallery was added, dedicated to the reproductions of the Cholula mural paintings, since the originals are not open to the public.

The display was refreshed in 1997 and in 2007 another alteration took place due to the replacement of part of the building and the removal of part of the collection. The 1997 exhibition plan was retained, apart from the incorporation of a section dedicated to the moment of contact with the Spanish conquistadors, set in context by a key item from the collection, the historical facsimile painted in oils reproducing part of the Cholula Codex.

This site museum’s three galleries follow a chronological plan displaying an essentially archeological collection which features ceramics, stone, bone and shell artifacts, and with a smaller historical collection with some ceramics and oil paintings on canvas. The museum texts are in Spanish and English. In 2015 the whole collection of the Cholula Archeological Site Museum consisting of 265 items was registered in the Unified Registry System for Public Monuments and Archeological and Historical Sites.

The museum building does not have its own washrooms, and visitors have to use the facilities at the Cholula archeological site. These are located in the Public Services Module adjacent to the museum precinct. The archeological site’s main ticket office is in the Great Pyramid’s access tunnel, in front of this Module. Entry tickets can be purchased giving access to three areas: the site museum, the tunnel inside the Great Pyramid (306 yards long) and the ceremonial patios to the south and west sides of the Great Pyramid of Cholula. Entry is free to any of the categories set out in the Federal Fees Law. The museum does not have a dedicated parking space for visitors nor does it offer guided tours on behalf of INAH. The guides who provide services in English and Spanish have been certified by the Ministry of Tourism.